Visceral Leishmaniasis

This two-page spread overviews the pathophysiology of visceral leishmaniasis—also known as Kala Azar, or black fever. The dynamic flow of the illustration around the text intended to provide the viewer with a panorama that interweaved time and scale. The storyline encompasses the vector transmission of the Leishmania Donovani parasite into the phlebotomine sand fly, maturation of the parasite, migration into the human host, uptake of the parasite by neutrophils and subsequent silent entry into resident macrophages, division, rupture, and release of the amastigote form of the parasite into the peripheral blood and tissues, and the subsequent destructive effects within the liver and spleen.